Steve Ealick's Research Group

Katie McCulloch

Email: kmm95@cornell.edu

BS: Chemistry, Ball State University, 2004

MS: Chemistry, Cornell University, 2006

Experience:

Sixth year graduate student in Chemistry

Current Projects:

Crystallization and X-ray analysis of proteins associated with thiamin biosynthesis
Crystallization and X-ray analysis of multifunctional enzymes in the purine biosynthetic pathway
Crystallization and X-ray analysis of enzymes in the PLP catabolism pathway

Publications:

Mukherjee T, McCulloch KM, Ealick SE and Begley TP. Gene identification and structural characterization of the PLP degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from Mesorhizobium loti MAFF303099. Biochemistry 46:13606-13615 (2007). Abstract. PubMed.

McCulloch KM, Kinsland C, Begley TP, and Ealick SE. Structural Studies of Thiamin Monophosphate Kinase in Complex with Substrates and Products. Biochemistry. Biochemistry 47: 3810-3821 (2008). Abstract. PubMed.

McCulloch KM, Mukherjee T, Begley TP and Ealick SE. Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase from Mesohizobium loti MAFF303099 and its Mechanistic Implications. Biochemistry 48, 4139-4149 (2009). Abstract PubMed