Steve Ealick's Research Group
Begley TP, Ealick SE, and McLafferty FW. Thiamin biosynthesis: still yielding fascinating biological chemistry. Biochem. Soc. Trans. 40:555-60 (2012).
The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.
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