Steve Ealick's Research Group
Mehta AP, Abdelwahed S, Mahanta N, Fedoseyenko D, Philmus B, Cooper L, Liu Y, Jhulki I, Ealick SE, and Begley TP. Radical SAM Enzymes in Cofactor Biosynthesis: a treasure trove of complex organic radical rearrangement reactions. J. Biol. Chem. 290: 3980-3986 (2015).
In this review, we will describe the radical SAM enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420 and heme. Our focus will be on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.
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