Publications

Steve Ealick's Research Group

Publications

Recent Publications

Chatterjee, A, Schroeder FC, Jurgenson CT, Ealick SE, and Begley TP. Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate. J. Am. Chem. Soc. Accepted. Abstract. PubMed.

Morar M, Hoskins AA, Stubbe J, and Ealick SE. Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation. Biochemistry 47:7816-7830 (2008). Abstract. PubMed.

Begley, TP, Chatterjee, A, Hanes, JW, Hazra, A, and Ealick, SE. Cofactor Biosynthesis-Still Yielding Fascinating New Biological Chemistry. Curr. Opin. Chem. Biol. 12:118-125 (2008). Abstract. PubMed.

Müller IB, Knöckel J, Groves MR, Jordanova R, Ealick SE, Walter RD, and Wrenger C. The Assembly of the Plasmodial PLP Synthase Complex Follows a Defined Course. PLoS ONE 3:e1815 (2008). Abstract. PubMed. PubMedCentral

McCulloch KM, Kinsland C, Begley TP, and Ealick SE. Structural Studies of Thiamin Monophosphate Kinase in Complex with Substrates and Products. Biochemistry 47: 3810-3821 (2008). Abstract. PubMed.

Soriano EV, McCloskey DE, Kinsland C, Pegg AE and Ealick SE. *Soriano EV, McCloskey DE, Kinsland C, Pegg AE and Ealick SE. Structures of the N47A and E109Q Mutant Proteins of Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii. Acta Crystallogr. D 64:377-382 (2008). Abstract. Reprint (pdf). Journal Link PubMed

Soriano EV, Rajashankar KR, Hanes JW, Bale S, Begley TP and Ealick SE. Structural Similarities between Thiamin-Binding Protein and Thiaminase-I Suggest a Common Ancestor. Biochemistry 47:1346-1357 (2008). Abstract. PubMed.

Zhang Y, White RH and Ealick SE. Crystal Structure and Function of 5-Formaminoimidazole-4-carboxamide-1-b-D-ribofuranosyl 5-Monophosphate Synthetase from Methanocaldococcus jannaschii. Biochemistry 47:205-217 (2008). Abstract. PubMed. Also reports a possible "PurP2", that is as yet functionally uncharacterized.

Jenkins AL, Zhang Y, Ealick SE and Begley TP. Mutagenesis studies on TenA: A thiamin salvage enzyme from Bacillus subtilis. Bioorg. Chem. 36:29-32 (2008). Abstract. PubMed.

Soriano EV, Clark VC, and Ealick SE. Crystal Structure of Human Deoxycitidine Kinase Product Complexes. Acta Crystallogr. D 63:1201-1207 (2007). Abstract. PubMed.

Mukherjee T, McCulloch KM, Ealick SE and Begley TP. Gene identification and structural characterization of the PLP degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from Mesorhizobium loti MAFF303099. Biochemistry 46:13606-13615 (2007). Abstract. PubMed.

Mathews, FS, Gordon, MM, Chen, Z, Rajashankar, KR, Ealick, SE, Alpers, DH, and Sukumar, N. Crystal structure of human intrinsic factor: Cobalamin complex at 2.6-Å resolution. Proc. Natl. Acad. Sci. U. S. A. 104:17311-17316 (2007). Abstract. PubMed.

Morar M, White RH and Ealick SE. Structure of 2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic Acid Synthase, a Catalyst in a Novel Pathway for the Biosynthesis of Aromatic Amino Acids. Biochemistry 46:10562-10571(2007). Abstract. PubMed.

Brooks WH, WH, McCloskey DE, Daniel KG, Ealick SE, Secrist III JA, Waud WR, Pegg AE, and Guida WC. In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase. J. Comp. Inf. Model. 47:1897-1905 (2007). Abstract. PubMed

Zhang Y and Ealick SE. The Changing Landscape in Drug Discovery Purine Nucleoside Phosphorylase. in "Computational and Structural Approaches to Drug Discovery Ligand-Protein Interactions", Stroud RM and Finer-Moore J, eds., Royal Society of Chemistry, London (2007). ISBN 0854043659.

Wang, J, Ogata, C, Yang, X, Sukumar, N, Kourinov, I, Capel, M, Lynch, AE, Rajashankar, Withrow, J, and Ealick, S. NE-CAT upgrade of the bending magnet beamline 8BM at the APS, AIP Conference Proceedings 879, 832-835 (2007). Abstract.

Ealick SE and Begley TP. Biochemistry: molecular cannibalism. Nature 446:387-388 (2007). Abstract. PubMed.

Hanes J, Ealick SE and Begley TP. Thiamin Phosphate Synthase: The Rate of Pyrimidine Carbocation Formation. J. Am. Chem. Soc. 129:4860-4861(2007). Abstract. PubMed.

Kang Y-N, Tran A, White RH and Ealick SE. A Novel Function for the NTN Hydrolase Fold Demonstrated by the Structure of an Archeal Inosine Monophosphate Cyclohydrolase. Biochemistry 46:5050-5062 (2007). Abstract. PubMed.

Chatterjee A, Jurgenson CT, Schroeder FC, Ealick SE, and Begley TP. Biosynthesis of the Thiamin Thiazole in Eukaryotes: The Conversion of NAD to an Advanced Intermediate. J. Am. Chem. Soc. 129:126-134 (2007). Abstract. PubMed

Hoskins AA, Morar M, Kappock TJ, Mathews II, Zaugg JB, Barder TE, Peng P, Okamoto A, Ealick SE, and Stubbe J. N⁵-CAIR Mutase: the Role of a CO₂ Binding Site and Substrate Movement in Catalysis. Biochemistry 46:2846-2855 (2007). Abstract. PubMed.

Zhang Y, el Kouni MH and Ealick SE. Substrate Analogs Induce an Intermediate Conformational Change in Toxoplasma gondii Adenosine Kinase. Acta Crystallogr. D. 63:126-134 (2007). Abstract. PubMed.

Zhang Y, Kang SA, Mukherjee T, Bale S, Crane BR, Begley TP and Ealick SE. Crystal Structure and Mechanism of Tryptophan 2,3-Dioxygenase, a Heme Enzyme Involved in Tryptophan Catabolism and in Quinolinate Biosynthesis. Biochemistry 46:145-155 (2007). Abstract. PubMed.

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