Publications

Steve Ealick's Research Group

Publications

Recent Publications

Bale S, Guida WC, Brooks WH, Hanes JW, Mahesan AM and Ealick SE. Role of the Sulfonium Center in Determining Ligand Specificity of Human S-Adenosylmethionine Decarboxylase. Biochemistry (in press). Abstract. PubMed.

McCulloch KM, Mukherjee T, Begley TP and Ealick SE. Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase from Mesohizobium loti MAFF303099 and its Mechanistic Implications. Biochemistry 48:4139-4149 (2009). Abstract PubMed

Jurgenson CT, Ealick SE, and Begley TP. (2009) 13 February 2009, posting date; Chapter 3.6.3.7 Biosynthesis of Thiamine Pyrophosphate, in EcolSal – Escherichia coli and Salmonella: cellular and molecular biology (Böck, A., Curtiss III, R., Kaper, J. B., Neidhardt, F. C., Nyström, T., Rudd, K. E., and Squires, C. L., Eds.), ASM Press, Washington, D.C. (invited review; book chapter) Abstract URL

Jurgenson CT, Begley TP, and Ealick SE. The Structural and Biochemical Foundations of Thiamin Biosynthesis, Annu. Rev. Biochem. 78:569-603 (2009). Abstract PubMed

O'Leary SE, Hicks KA, Ealick SE, and Begley TP. Biochemical Characterization of the HpxO Enzyme from Klebsiella pneumoniae, a Novel FAD Dependent Urate Oxidase. Biochemistry 48:3033-3035 (2009). Abstract PubMed

McCloskey DE, Bale S, Secrist JA III, Tiwari A, Moss TH III, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, and Ealick SE. (2009) New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C⁸ Substitution in Structural Analogues of S-Adenosylmethionine. J. Med. Chem. 52:1388-1407 (2009). Abstract PubMed

Sukumar N, Mathews FS, Gordon MM, Ealick SE, and Alpers DH. Postcrystallization Analysis of the Irreproducibility of the Human Intrinsic Factor-Cobalamin Complex Crystals. Cryst. Growth Des. 9:348-351 (2009). Abstract URL

Bale S, Lopez MM, Makhatadze G; Fang QI; Pegg AE, and Ealick SE. Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry 47:13404-13417 (2008). Abstract. PubMed

Chatterjee A, Li S, Zhang Y, Grove TL, Lee M, Krebs C, Booker SJ, and Begley TP, and Ealick SE. Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat. Chem. Biol. 4:758-765 (2008). Abstract PubMed

O'Leary S, Jurgenson CT, Ealick SE, and Begley TP. O-Phospho-L-serine and the Thiocarboxylated Sulfur Carrier Protein CysO-COSH are Substrates for CysM, a Cysteine Synthase from Mycobacterium tuberculosis. Biochemistry 47:11606-11615 (2008). Abstract. PubMed

Jurgenson, CT, Burns, KE, Begley, TP, and Ealick, SE. Crystal Structure of a Sulfur Carrier Protein Complex Found in the Cysteine Biosynthetic Pathway of Mycobacterium tuberculosis. Biochemistry 47:10354-10364 (2008). Abstract. PubMed

Zhang Y, Morar M and Ealick SE. Structural Biology of the Purine Biosynthetic Pathway. Cell. Mol. Life Sci. 65:3699-3724 (2008). Abstract. PubMed Supplemental Material

Chatterjee, A, Schroeder FC, Jurgenson CT, Ealick SE, and Begley TP. Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate. J. Am. Chem. Soc.130:11394-11398 (2008). Abstract. PubMed.

Morar M, Hoskins AA, Stubbe J, and Ealick SE. Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation. Biochemistry 47:7816-7830 (2008). Abstract. PubMed.

Begley TP, Chatterjee A, Hanes JW, Hazra A, and Ealick SE. Cofactor Biosynthesis-Still Yielding Fascinating New Biological Chemistry. Curr. Opin. Chem. Biol. 12:118-125 (2008). Abstract. PubMed.

Müller IB, Knöckel J, Groves MR, Jordanova R, Ealick SE, Walter RD, and Wrenger C. The Assembly of the Plasmodial PLP Synthase Complex Follows a Defined Course. PLoS ONE 3:e1815 (2008). Abstract. PubMed. PubMedCentral

McCulloch KM, Kinsland C, Begley TP, and Ealick SE. Structural Studies of Thiamin Monophosphate Kinase in Complex with Substrates and Products. Biochemistry 47: 3810-3821 (2008). Abstract. PubMed.

Soriano EV, McCloskey DE, Kinsland C, Pegg AE and Ealick SE. Structures of the N47A and E109Q Mutant Proteins of Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii. Acta Crystallogr. D 64:377-382 (2008). Abstract. Journal Link PubMed

Soriano EV, Rajashankar KR, Hanes JW, Bale S, Begley TP and Ealick SE. Structural Similarities between Thiamin-Binding Protein and Thiaminase-I Suggest a Common Ancestor. Biochemistry 47:1346-1357 (2008). Abstract. PubMed.

Zhang Y, White RH and Ealick SE. Crystal Structure and Function of 5-Formaminoimidazole-4-carboxamide-1-b-D-ribofuranosyl 5-Monophosphate Synthetase from Methanocaldococcus jannaschii. Biochemistry 47:205-217 (2008). Abstract. PubMed. Also reports a possible "PurP" fromPyrococcus furiosus, that is as yet functionally uncharacterized.

Jenkins AL, Zhang Y, Ealick SE and Begley TP. Mutagenesis studies on TenA: A thiamin salvage enzyme from Bacillus subtilis. Bioorg. Chem. 36:29-32 (2008). Abstract. PubMed.

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