Steve Ealick's Research Group Recent Publications

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Sikowitz MD, Cooper LE, Begley TP, Kaminski PA, and Ealick SE. Reversal of Substrate Specificity of CMP N-glycosidase to dCMP. Biochemistry 52:4037–4047 (2013). Abstract PubMed (Reports structures of both Clostridium botulinum BcmB and Saccharomyces rimofaciens MilB)

Hicks KA, O'Leary SE, Begley TP, and Ealick SE. Structural and Mechanistic Studies of HpxO, a Novel FAD-dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry 52:477-487 (2013). Abstract PubMed

Huang S, Mahanta N, Begley TP, and Ealick SE. Pseudouridine Monophosphate Glycosidase: A New Glycosidase Mechanism. Biochemistry 51:9245-9255 (2012). Abstract. PubMed

Knaus T, Eger E, Koop J, Stipsits S, Kinsland CL, Ealick SE, and Macheroux P. Reverse structural genomics: An unsual flavin binding site in a putative protease from Bacteroides thetaiotaomicron, J. Biol. Chem. 287:27490-27498 (2012). Abstract PubMed

Lai RY, Huang S, Fenwick MK, Hazra AB, Zhang Y, Rajashankar KR, Philmus B, Kinsland C, Sanders JM, Ealick SE, and Begley TP. Thiamin pyrimidine biosynthesis in Candida albicans: a remarkable reaction between histidine and pyridoxal phosphate. J. Am. Chem. Soc. 134:9157−9159. (2012). Abstract. PubMed

Begley TP, Ealick SE, and McLafferty FW. Thiamin biosynthesis: still yielding fascinating biological chemistry. Biochem. Soc. Trans. 40:555-60 (2012). Abstract. PubMed

Dessanti P, Zhang Y, Allegrini S, Tozzi MG, Sgarrella F, and Ealick SE. Structural basis of the substrate specificity of Bacillus cereus adenosine phosphorylase. Acta Crystallogr. D 68:239-248 (2012). Abstract. PubMed. Pdf. Reference

Zhang Y, Zwart PH, and Ealick SE. A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II. Acta Crystallogr. D 68:249-252 (2012). Abstract. PubMed. Pdf. Reference

Philmus B, Abdelwahed S, Williams HJ, Fenwick MK, Ealick SE, and Begley TP. Identification of the product of Toxoflavin lyase: degradation via a Baeyer-Villiger oxidation. J. Am. Chem. Soc. 134:5326-5330. (2012). Abstract PubMed