Steve Ealick's Research Group

Sarcoplasmic Calcium-binding Protein from Nereis diversicolor

PDB file: 2SCP


Sarcoplasmic calcium-binding proteins (SCPs) are an important Ca2+-binding system in muscles of both vertebrate and invertebrate species. The SCP from the sandworm Nereis diversicolor is a single polypeptide chain of 174 amino acids and a molecular mass of 19,485 daltons. There are three calcium binding sites, which may be occupied by magnesium ions under physiological conditions. We determined the three-dimensional structure of Nereis diversicolor SCP at 3 Å resolution, using multiple isomorphous replacement techniques.

This drawing of Nereis diversicolor SCP is based on the Cα positions. The three calcium ions are represented by gray spheres.

Click the image to enlarge.


Cook WJ, Ealick SE, Vijay-Kumar S, Babu YS, and Cox JA. Three-dimensional Structure of Sarcoplasmic Calcium-binding Protein from Nereis diversicolor. J. Biol. Chem. 266(1):652-656 (1991).

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